Quantum sensors make microscale NMR spectroscopy possible

A mini-magnetic resonance tomograph made of diamond

Press release /

The development of tumors begins with miniscule changes within the body's cells; ion diffusion at the smallest scales is decisive in the performance of batteries. Until now the resolution of conventional imaging methods has not been high enough to represent these processes in detail. A research team lead by the Technical University of Munich (TUM) and including Fraunhofer IAF has developed diamond quantum sensors which can be used as high-resolution magnetic resonance tomographs.

Diamond provided by Fraunhofer IAF used as a quantum sensor for microscale NMR
© Technical University of Munich | Andreas Heddergott
Diamond with nitrogen-vacancy (NV) centers used as quantum sensors for microscale NMR in the experimental setup
Researchers work on an optical setup for microscopic NMR spectroscopy
© Technical University of Munich | Andreas Heddergott
A research team led by the Technical University of Munich has developed a novel NMR method that can detect microstructures using diamond-based quantum sensors.

Nuclear magnetic resonance (NMR) is an important imaging method in research which can be used to visualize tissue and structures without damaging them. The process is better known from the medical field as Magnetic Resonance Imaging (MRI), where the patient is moved through a large tube on a table. The MRI device creates a very strong magnetic field which interacts with the tiny, weak magnetic fields of the hydrogen nuclei in the body. Since the hydrogen atoms are distributed characteristically in different types of tissue, it becomes possible to differentiate organs, joints, muscles and blood vessels.

NMR methods can also be used to visualize the diffusion of water and other elements. Research for example often involves observing the behavior of carbon or lithium in order to explore the structures of enzymes or processes in batteries. “Existing NMR methods provide good results, for example when it comes to recognizing abnormal processes in cell colonies,” says Dominik Bucher, Professor of Quantum Sensing at TUM. “But we need new approaches if we want to explain what happens in the microstructures within the cells.”

Sensors made of diamond

The research team produced a quantum sensor made of synthetic diamond for this purpose. “We enrich the diamond layer, which we provide for the new NMR method, with special nitrogen and carbon atoms already during growth,” explains Dr. Peter Knittel of the Fraunhofer Institute for Applied Solid State Physics IAF.

After growth, electron irradiation detaches individual carbon atoms from the diamond's perfect crystal lattice. The resulting defects arrange themselves next to the nitrogen atoms — a so-called nitrogen-vacancy center has been created. This has quantum mechanical properties. “Our processing of the material optimizes the duration of the quantum states, which allows the sensors to measure for longer,” adds Knittel.

Quantum sensors pass the first test

The quantum state of the nitrogen-vacancy centers interacts with magnetic fields. “The MRI signal from the sample is then converted into an optical signal which we can detect with a high degree of spatial resolution,” Bucher explains.

In order to test the method, the TUM scientists placed a microchip with microscopic water-filled channels on the diamond quantum sensor. “This let us simulate the microstructures of a cell,” says Bucher. The researchers were able to successfully analyze the diffusion of water molecules within the microstructure.

In the next step the researchers want to develop the method further to enable the investigation of microstructures in single live cells, tissue sections or the ion mobility of thin-film materials for battery applications. “The ability of NMR and MRI to directly detect the mobility of atoms and molecules makes them absolutely unique compared to other imaging methods,” says Prof. Maxim Zaitsev of the University of Freiburg. “Now we have found a way to also significantly improve their resolution.”


Fleming Bruckmaier et al., Imaging local diffusion in microstructures using NV-based pulsed field gradient NMR. Sci. Adv.9, eadh3484(2023).

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